About Therapeutic Oligos 2025:
A dynamic event allowing esteemed scientists from academia, industry, and the vendor community to convene.
Building upon the success of the inaugural Therapeutic Oligonucleotides meeting, this event facilitates an open environment for exploring the discovery, validation, and targeting of drug candidates using antisense oligonucleotides and siRNA.
Organised by ELRIG, a leading European not-for-profit organisation dedicated to uplifting the life science and drug discovery community.
Therapeutic Oligos is an open-access meeting that fosters an inspiring environment for networking, encouraging collaboration between biologists and chemists across diverse research areas.
Explainable AI for predictive modelling of drug properties.
Presentation given by Disa Tehler, Abzu’s Head of RNA Therapeutics at Therapeutic Oligos 2025 in Gothenburg.
Disa’s presentation showcases how we incorporate off-target prediction alongside other predictive drug property models and physicochemical features in order to capture synergistic effects between base sequences and chemical properties, enabling a holistic understanding of how these features influence therapeutic performance.
We demonstrate how this unified framework enhances the efficiency of drug development by enabling consistent modeling of diverse characteristics. It reduces the risk of late-stage failures and facilitates the creation of oligonucleotides with tailored profiles for activity, stability, and safety.
Our results demonstrate that explainable AI not only achieves high predictive accuracy but also provides actionable insights into the key drivers of drug performance. This methodology represents a significant advancement in predictive modeling for oligonucleotide drugs, offering a powerful tool to enhance safety, efficacy, and overall therapeutic success.
Missed the presentation? Download it here.
If you were unable to attend Disa’s talk or would like to revisit the information, you can download the slide deck for the presentation by filling out the form below.
Connecting with and learning from the community.
Disa, Martin Kerr (BD & Sales), Victor Galindo (CEO) and Kevin Broløs (Co-Founder) were present at the conference drawing inspiration from, and connecting with, academic researchers and industry professionals.
The open nature of this community and event was felt throughout. The event was buzzing with energy, inspiration and sharing of experiences from the presentations of numerous industry leaders and researchers, poster sessions and vendor showcases.
